T cell modular nomenclature generator

Composes a name from independently-evidenced slots — Lineage · Function · Migration · Differentiation state · Antigen status. A slot with no supporting marker data is left blank, never guessed.

Population identity
Migration override (optional)

If the markers below don't clearly support S or D, this slot is left blank by default — per the paper, migration is an optional descriptor, and lack of evidence doesn't force a 'U'. Only set this if you want to explicitly assert 'U' (or an S/D that differs from the markers) as a claim.

Migration (CD62L / CCR7)

Determines S (can enter lymph nodes) vs D (disseminated).

CD62L
L-selectin. Needed to enter lymph nodes through HEVs.
CCR7
Chemokine receptor that guides homing to lymph nodes.
Naive vs. memory (CD45RA / CD45RO / CD95)

Determines the Naive (N) call.

CD45RA
Isoform typically seen on naive (and some terminally-differentiated) T cells.
CD45RO
Isoform typically seen on memory T cells.
CD95
Fas. Used to separate true naive cells from stem-cell memory cells.
Recent activation (CD69 / CD25)

Determines the Activated (A) call, together with PD1/TOX below.

CD69
Early marker of recent TCR/cytokine activation.
CD25
IL-2 receptor alpha chain; induced by recent activation.
Chronic stimulation / exhaustion (PD1 / TOX)

PD1+ and TOX+ together determine the Exhausted (X) call.

PD1
Inhibitory receptor induced by chronic antigen stimulation.
TOX
Transcription factor that drives the exhaustion program.
Exhaustion subtype (TCF1 / SLAMF6 / TIM3 / CD101)

Only relevant if X was called above — splits it into progenitor (p) or terminal (t).

TCF1
Transcription factor that maintains stem-like/progenitor exhausted cells.
SLAMF6
Surface marker associated with progenitor exhausted cells.
TIM3
Surface marker associated with terminally exhausted cells.
CD101
Surface marker associated with terminally exhausted cells.
Activated/memory subtype (KLRG1 / CD127 / CD27)

Refines Activated into progenitor (Ap) / terminal (At), and Memory into stem-cell-like progenitor (Mp).

KLRG1
Killer cell lectin-like receptor; marks short-lived terminal effector cells.
CD127
IL-7 receptor alpha; lost on short-lived effectors, retained on memory-precursor/stem-like cells.
CD27
Co-stimulatory receptor retained on memory-precursor and stem-cell memory cells.
Migration subscript

Never inferred from markers — only set this if you have explicit additional assay evidence. Which combinations are valid depends on the Migration result above: B applies to S/D/U, W applies to S/D, R applies to D only.

Differentiation override

Anergic (G) is functionally defined and can't be read off markers — set it here with a justification if applicable.

Antigen status

Never inferred from markers — depends on your experimental design.

Reset
CD4+ TSN
LineageCD4+
Function(not given)
MigrationS
DifferentiationN
Antigen status(not asserted)
Why (audit trail — check this before trusting the name)
  • Migration: S: CD62L+ and CCR7+ (both confirmed positive) -> can enter secondary lymphoid organs.
  • Differentiation: N: naive criteria met (CCR7=+, CD45RA=+, CD45RO=NA, CD95=-).
  • Antigen status: Antigen status not asserted by user (no claim made).